Table 1.
Formulation | Composition (weight%)
|
Particle size (nm)
|
|||
---|---|---|---|---|---|
Cremophor EL | Ethanol | Glycerin | Mean diameter | Transparency | |
Ethanol 0 system | |||||
Z1 | 0.01 | 0 | 2.2 | – | – |
Z2 | 0.05 | 0 | 2.2 | – | – |
Z3 | 0.5 | 0 | 2.2 | – | – |
Z4 | 1 | 0 | 2.2 | – | – |
Z5 | 3 | 0 | 2.2 | 17.50±0.26 | ✓ |
Z6 | 4 | 0 | 2.2 | 17.73±0.15 | ✓ |
Z7 | 5 | 0 | 2.2 | 17.27±0.31 | ✓ |
Ethanol 0.5% system | |||||
F1 | 0.01 | 0.5 | 2.2 | 359.43±6.1 | × |
F2 | 0.05 | 0.5 | 2.2 | 192.13±3.76 | × |
F3 | 0.5 | 0.5 | 2.2 | 213.93±6.97 | × |
F4 | 1 | 0.5 | 2.2 | 14.73±0.21 | ✓ |
F5 | 3 | 0.5 | 2.2 | 17.3±0.1 | ✓ |
F6 | 4 | 0.5 | 2.2 | 17.53±0.38 | ✓ |
F7 | 5 | 0.5 | 2.2 | 17.33±0.29 | ✓ |
Ethanol 1% system | |||||
O1 | 0.01 | 1 | 2.2 | 199.77±7.23 | × |
O2 | 0.05 | 1 | 2.2 | 168.1±2.4 | × |
O3 | 0.5 | 1 | 2.2 | 245.17±4.31 | × |
O4 | 1 | 1 | 2.2 | 14.53±0.4 | ✓ |
O5 | 3 | 1 | 2.2 | 17.37±0.25 | ✓ |
O6 | 4 | 1 | 2.2 | 17.53±0.06 | ✓ |
O7 | 5 | 1 | 2.2 | 17.2±0.3 | ✓ |
Notes: Z1–Z4 did not form micelle solutions in this study. Transparency was assessed visually. Data expressed as mean ± standard deviation (n=3). “✓” Transparent micelle solution; “×” non-transparent solution; “–” not formed solution.