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. 2016 Jun 21;11:2921–2933. doi: 10.2147/IJN.S107569

Table 3.

pH and osmolarity analysis of different micelle formulations

Formulation pH
Osmolarity (mOsm)
Initial pH After 60 days Increasing ratioa Initial osmolarity After 60 days Increasing ratiob
Stored at room temperature over 60 days
Z5 7.41±0.01 7.39±0.02 0.997 317.4±7.64 303.7±4.62 0.957
Z6 7.42±0.02 7.38±0.06 0.995 316.77±12.86 299.87±3.26 0.947
Z7 7.43±0.03 7.4±0.03 0.996 311±10.65 298.57±3.95 0.96
F5 7.43±0.03 7.41±0.03 0.997 305.5±3.51 296.6±13.67 0.971
F6 7.47±0.02 7.41±0.02 0.992 298.30±9.54 304.4±5.03 1.02
F7 7.44±0.01 7.4±0.01 0.995 299.63±2.68 296.6±10.82 0.99
O5 7.42±0.03 7.42±0.05 1 309.53±12.11 301.67±4 0.975
O6 7.46±0.01 7.4±0.05 0.992 311.13±4.3 297.47±2.95 0.956
O7 7.45±0.03 7.39±0.07 0.992 306.37±3.46 300.3±3.02 0.98
Stored at 4°C over 60 days
Z5 7.41±0.01 7.4±0.01 0.999 317.4±7.64 309.03±7.8 0.974
Z6 7.42±0.02 7.41±0.02 0.999 316.77±12.86 307.17±7.48 0.97
Z7 7.43±0.03 7.39±0.09 0.995 311±10.65 304.87±14.2 0.98
F5 7.43±0.03 7.41±0.08 0.997 305.5±3.51 297.7±7.57 0.974
F6 7.47±0.02 7.37±0.05 0.987 298.3±9.54 300.13±2.99 1.006
F7 7.44±0.01 7.41±0.04 0.996 299.63±2.68 303.27±10.05 1.012
O5 7.42±0.03 7.39±0.06 0.996 309.53±12.11 302±9.24 0.976
O6 7.46±0.01 7.39±0.07 0.991 311.13±4.3 298.27±3.7 0.959
O7 7.45±0.03 7.42±0.03 0.996 306.37±3.46 300.03±5.02 0.979

Notes:

a

Increasing ratio = pH after 60 days/initial pH;

b

increasing ratio = osmolarity after 60 days/initial osmolarity. Data expressed as mean ± standard deviation (n=3). Information about the formulation names is shown in Table 1.