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. Author manuscript; available in PMC: 2016 Aug 12.
Published in final edited form as: J Am Chem Soc. 2015 Jul 30;137(31):9885–9893. doi: 10.1021/jacs.5b04520

Figure 1.

Figure 1

Chemical modularity in building fungal polyketides. A) Representative molecules. The red portion indicates reduced products of upstream synthases that are transferred to downstream NR-PKSs. B) Proposed biosynthesis of chaetoviridin A (6) and chaetomugilin A (7). Domain abbreviations:ketosynthase (KS), malonyl-CoA:acyl carrier protein acyltransferase (MAT), dehydratase (DH), methyltransferase (MT), enoylreductase (ER), ketoreductase (KR), acyl carrier protein (ACP), starter-unit:ACP-transacylase (SAT), product template (PT), and reductive domain (R). 11-SNAC was synthesized and used to directly load the KS of CazM.