Table 3.
Pharmacokinetic parameters of 10-HCPT in Sprague Dawley rat plasma after intravenous administration of 10-HCPT injections and 10-HCPT nanocrystals
| Group | t1/2 (h) | AUC0–24 h (ng⋅mL−1⋅h) | Cl (mL/h) | MRT (h) |
|---|---|---|---|---|
| 10-HCPT Inj | 0.62±0.1 | 1,735.9±135.5 | 484.99±23.4 | 1.4594±0.2 |
| 10-HCPT NCs | 1.85±0.1** | 4,867.7±46.3* | 10.65±7.6** | 10.35±0.2** |
Notes: The results are presented as mean ± SD, n=10.
*
P<0.01
**
P<0.001.
Abbreviations: 10-HCPT, 10-hydroxycamptothecin; AUC0–24 h, area under the curve within 24 hours; Cl, clearance; Inj, injections; MRT, mean residence time; NCs, nanocrystals; t1/2, terminal elimination half-life; SD, standard deviation.