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. 2016 Jun 23;22:2152–2160. doi: 10.12659/MSM.899419

Figure 4.

Figure 4

Effect of astaxanthin (ASX) on H22 cells cell cycle by flow cytometry. (A) In vitro, H22 cells were treated with 0.1% DMSO (the control group), 40 μM cisplatin (positive control group), 20 and 40 μM ASX for 6 hours, 12 hours and 24 hours. (a) Control group; (b) Positive control group; (c) Low-dose ASX group (20 μM); (d) High-dose ASX group (40 μM). (B) In vivo, mice were administered ASX with 2 or 4 μg/kg body weight through intragastric administration every day for 7 days, and the control group was administered with equivalent saline. After H22 cells were administered by intraperitoneal injection, H22 cells in ascites were measured. (a) Control group; (b) Low-dose ASX group (2 μg/kg body weight); (c) High-dose ASX group (4 μg/kg body weight). The proportion of S phase was decreased, and the proportion of G2 phase was increased in the ow-dose ASX and high-dose ASX groups compared to the control group.