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. 2016 May 23;49(2):479–486. doi: 10.3892/ijo.2016.3534

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Copyright: © Thulasiraman et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Honokiol suppresses the expression level of ABBC1/MRP1 in mammary carcinoma cells. Total RNA was collected from MCF-7 cells (A) and MDA-MB-231 (B) cells treated with 10 or 20 μM honokiol for 48 h (DMSO was used for the control). Expression level of ABCC1 mRNA in MCF-7 cells (A) and MDA-MB-231 cells (B) were analyzed by qRT-PCR. GAPDH was used for normalization. Data are mean of ± SE (n=3). ^*p=0.0006 versus control treatment; ^**p=0.016 versus control treatment; ⁺p=0.01 versus control treatment; ⁺⁺p=0.004 versus control treatment. MCF-7 (C) and MDA-MB-231 (D) cells were treated with 10 or 20 μM honokiol for 48 h (DMSO was used for the control) prior to cell lysis. Cell lysates were resolved with SDS-PAGE and immunoblotted with antibodies recognizing MRP1, and β-tubulin was used as a loading control.