Table 2.
Baseline Characteristics: STOPDAPT versus RESET
| STOPDAPT (N = 1525) | RESET (N = 1559) | P value | |
|---|---|---|---|
| Age (years) | 70.0 ± 10.6 | 68.9 ± 9.7 | 0.002 |
| Age ≥75 yearsa | 570 (37 %) | 480 (31 %) | 0.0001 |
| Male gendera | 1117 (73 %) | 1213 (78 %) | 0.003 |
| Body mass index | 24.1 ± 3.6 | 24.3 ± 3.6 (1542) | 0.25 |
| Coexisting condition | |||
| Hypertensiona | 1261 (83 %) | 1238 (79 %) | 0.02 |
| Diabetes mellitusa | 604 (40 %) | 707 (45 %) | 0.001 |
| Insulin-treated diabetes | 119 (7.8 %) | 171 (11 %) | 0.003 |
| Treated with oral medication only | 360 (24 %) | 343 (22 %) | 0.29 |
| Treated with diet therapy only | 125 (8.2 %) | 193 (12 %) | 0.0001 |
| Dyslipidemia | 1209 (79 %) | 1164 (75 %) | 0.002 |
| ESRD (eGFR < 30 mL/min/1.73 m2) not on hemodialysis | 35/1521 (2.3 %) | 31/1552 (2.0 %) | 0.56 |
| Hemodialysisa | 56 (3.7 %) | 90 (5.8 %) | 0.006 |
| Atrial fibrillation | 172 (11 %) | 104 (6.7 %) | <0.0001 |
| Anemia (hemoglobin <11.0 g/dL)a | 241 (16 %) | 190 (12 %) | 0.004 |
| Cardiac risk factor | |||
| Current smoker | 315 (21 %) | 329 (21 %) | 0.76 |
| Family history of coronary artery disease | 192 (13 %) | 248/1343 (18 %) | <0.0001 |
| Prior myocardial infarction | 267 (18 %) | 459 (29 %) | <0.0001 |
| Prior strokea | 168 (11 %) | 176 (11 %) | 0.81 |
| Heart failure | 101 (6.6 %) | 138 (8.9 %) | 0.02 |
| Peripheral vascular disease | 142 (9.3 %) | 140 (9.0 %) | 0.75 |
| Prior percutaneous coronary intervention | 468 (31 %) | 741 (48 %) | <0.0001 |
| Prior coronary artery bypass grafting | 41 (2.7 %) | 61 (3.9 %) | 0.06 |
| Clinical characteristics | |||
| Clinical presentation | |||
| Stable coronary artery disease | 1040 (68 %) | 1282 (82 %) | <0.0001 |
| Unstable angina | 229 (15 %) | 175 (11 %) | 0.002 |
| Acute myocardial infarctiona | 256 (17 %) | 102 (6.5 %) | <0.0001 |
| Left ventricular ejection fraction <30 % | 17/1315 (1.3 %) | 24/1345 (1.8 %) | 0.3 |
| Multi-vessel disease | 578 (38 %) | 759 (49 %) | <0.0001 |
| Target-vessel location | |||
| Left main coronary arterya | 17 (1.1 %) | 46 (3.0 %) | 0.0002 |
| Left anterior descending coronary artery | 866 (57 %) | 762 (49 %) | <0.0001 |
| Left circumflex coronary artery | 361 (24 %) | 393 (25 %) | 0.32 |
| Right coronary artery | 405 (27 %) | 511 (33 %) | 0.0002 |
| Bypass graft | 4 (0.3 %) | 6 (0.4 %) | 0.55 |
| Complexity of coronary artery disease | |||
| Number of treated lesions per patient | 1.21 ± 0.48 | 1.23 ± 0.51 | 0.16 |
| Medications | |||
| Aspirin | 1524 (99.9 %) | 1553 (99.6 %) | 0.049 |
| Thienopyridines | 1522 (99.8 %) | 1552 (99.6 %) | 0.21 |
| Clopidogrel | 1508 (99.1 %) | 1350 (87 %) | <0.0001 |
| Ticlopidine | 14 (0.9 %) | 200 (13 %) | |
| Statins | 1223 (80 %) | 1207 (77 %) | 0.06 |
| B-blockers | 620 (41 %) | 566 (36 %) | 0.01 |
| ACE-I/ARB | 939 (62 %) | 967 (62 %) | 0.8 |
| Calcium-channel blockers | 675 (44 %) | 670 (43 %) | 0.47 |
| Nitrates | 219 (14 %) | 426 (27 %) | <0.0001 |
| Anticoagulantsa | 168 (11 %) | 125 (8.0 %) | 0.005 |
| Warfarin | 125 (8.2 %) | 125 (8.0 %) | |
| Dabigatran | 34 (2.2 %) | 0 (0 %) | |
| Rivaroxaban | 9 (0.6 %) | 0 (0 %) | |
| Lesion and Procedural characteristics | |||
| Before index procedure | |||
| Chronic total occlusion | 72 (4.7 %) | 109 (7.0 %) | 0.007 |
| Culprit for STEMI | 203 (13 %) | 69 (4.4 %) | <0.0001 |
| Bifurcation | 317 (21 %) | 337 (22 %) | 0.57 |
| After index procedure | |||
| Number of stents used per patient | 1.37 ± 0.65 | 1.5 ± 0.77 (1554) | <0.0001 |
| Total stent length per patient (mm) | 32.9 ± 20.9 | 30.8 ± 18.9 (1554) | 0.004 |
| Multi-vessel treatment | 130 (8.5 %) | 183 (12 %) | <0.0001 |
Values are expressed as mean ± SD or number (%)
ESRD end stage renal disease, eGFR estimated glomerular filtration rate, ACE-I angiotensin converting enzyme inhibitors, ARB angiotensin II receptor blockers, STEMI ST-segment elevation myocardial infarction
aPotential independent variables selected for multivariable analysis