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. 2016 Jun 28;4:52. doi: 10.3389/fbioe.2016.00052

Table 1.

Semiquantitative histomorphometric score modified by those of Svensson, Soslowsky, and Cook.

Parameter Grade 0 Grade 1 Grade 2 Grade 3
Fiber structure, Svensson and Soslowsky scores Normal appearance with collagen straight parallel and packed fibers, tangentially oriented with slight waviness Mild changes with collagen fibers <25% slightly separated with increased waviness Moderate changes with collagen fibers ≥25% and ≤50% disorganized, separated, and deteriorated Marked changes with collagen fibers >50% structurally disorganized, and hyalinized
Cellularity (aspect), Cook scores Inconspicuous elongated spindle nuclei with no obvious cytoplasm Increased roundness: nucleus becomes more ovoid to round in shape without conspicuous cytoplasm Increased roundness and size: the nucleus is round, slightly enlarged, and a small amount of cytoplasm is visible Nucleus is round and large with abundant cytoplasm and lacuna formation
Vascularity, Svensson scores Vessels run inconspicuous coursing parallel to the collagen fiber bundles in the septa Slight increase in vessels including transverse vessels in the tendon tissue Moderate increase in vessels within the tendon tissue Markedly increased vascularity with vessels
Cartilage formation No cartilage formation Isolated hyaline cartilage nodules Moderate cartilage formation of 25–50% Extensive cartilage formation, more than 50% of the field involved