Figure 1.

Schematic of modeling extracellular potential and recording from single neuronal compartment and neuronal ensembles. (A) Electrical equivalent circuit of granule cell model (Diwakar et al., 2009) with extracellular mechanism; Two layers of RC compartments added at the dendrite (indicative representation). (B) Cartoon of LFP electrode (microelectrode) recording from cerebellar granular layer ensemble. Schematic representation of different approximation techniques (C–E) used to model extracellular potential from detailed biophysical model of a neuronal compartment. (C) Each electrical source related to the neuronal compartment in Point Source Approximation (PSA) technique, is assumed to be at the center of the neuritic process. (D) In the Line Source Approximation (LSA) method, the electrical source was modeled as a line passing through the center of the neuritic volume. (E) The extracellular medium's low pass filtering properties was modeled as a Resistance-Capacitance (RC) filter.