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. 2016 Jun 28;4:29. doi: 10.3389/fchem.2016.00029

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Copyright © 2016 Ouellet.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Light-up aptamer as biosensors. (A) The engineered allosteric light-up aptamer is in a misfolded state and cannot bind a fluorogens. (B) Once the metabolite (orange sphere) binds the metabolite-binding aptamer, it promotes the folding of its own stem, which in turns stabilize the formation of the G-quadruplex. (C) The presence of the essential G-quadruplex and its surrounding nucleotides allows the fluorogen (green) to bind the modified light-up aptamer and releases its energy as fluorescence.