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. 2016 Jun 28;4(12):e12787. doi: 10.14814/phy2.12787

Figure 3.

Figure 3

Ca2+ current (IC a) recordings illustrating the effects of H89 and KN‐93 on PPN cells. All IC a were recorded using a multiple step depolarization protocol starting at −50 mV with 10 mV steps, up to 0 mV (top), but this figure shows only the −10 mV step. (A) IC a recorded from a PPN neuron (probably N + P/Q‐type) before (navy), after 10 min of H89 (red record, reduction), and 10 min of CgTx (green, block). (B) IC a from a PPN neuron (probably P/Q‐type) before (navy record), after 10 min of H89 (red, no effect), and 10 min of Aga (green record, block). (C) IC a recorded from a PPN neuron (probably N‐type) before (navy), after 10 min of H89 (red, block), and 20 min of H89 (green, block). (D) IC a recorded from a PPN neuron (probably N + P/Q‐type) before (navy record), after 10 min of KN‐93 (red, reduction), and 10 min of CgTx (green, block). (E) IC a from a PPN neuron (probably N‐type) before (navy), after 10 min of KN‐93 (red record, no effect), and 10 min of CgTx (green, block). (F) IC a recorded from a PPN neuron (probably P/Q‐type) before (navy), after 10 min of KN‐93 (red record, block), and 20 min of KN‐93 (green, block).