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. 2016 Jun 28;4(12):e12787. doi: 10.14814/phy2.12787

Figure 4.

Figure 4

Average current‐voltage (I‐V) curve of IC a from PPN neurons. Note that high‐threshold IC a peaked at ~−10 mV. (A) Representative IC a current–voltage plot from all PPN control neurons (n = 40) before treatment (black line). Red line shows maximum IC a (pA/pF) at min 10 for all PPN neurons (n = 12) that were exposed to H89. Blue line shows maximum IC a (pA/pF) for all PPN neurons (n = 10) that were exposed to H89 and Aga. (B) Representative IC a from all PPN control neurons (n = 40) before treatment (black line). Red line shows maximum IC a (pA/pF) at min 10 for all PPN neurons (n = 13) that were exposed to KN‐93. Blue line shows maximum IC a (pA/pF) for all PPN neurons (n = 11) that were exposed to KN‐93 and CgTx. (C) IC a recordings from a population of PPN neurons (n = 6) that were exposed to H89 and Aga sequentially. The black line represents the control condition. The red line represents IC a recordings after 10 min of H89. The blue line represents IC a recordings from neurons after 10 min of H89 and Aga. (D) IC a recordings from a population of PPN neurons (n = 7) that were exposed to KN‐93 and CgTx sequentially. The black line represents the control condition. The red line represents IC a recordings after 10 min of H89. The blue line represents IC a recordings from neurons after 10 min of H89 and Aga.