Table 3.
Top associations (pcorr < 0.10) with DMN components from the 7 candidate SNP analysis.
| Model parameter | DMN component | SNP | β | SE | t-value | p-value | pcorra |
|---|---|---|---|---|---|---|---|
| SNP main effect | Right Angular | rs130058 | −0.0608 | 0.0163 | −3.7125 | 0.0003 | 0.0154 |
| SNP × PTSD interactions | Right mPFC | rs7997012 | 0.0019 | 0.0005 | 3.9281 | 0.0001 | 0.0053 |
| Right MTG | rs7997012 | 0.0022 | 0.0006 | 3.6123 | 0.0004 | 0.0168 | |
| Right Angular | rs7997012 | 0.0017 | 0.0005 | 3.2582 | 0.0014 | 0.053 | |
| Left MTG | rs7997012 | 0.0018 | 0.0005 | 3.2014 | 0.0017 | 0.0664 |
a
P-corrected (pcorr) refers to estimate derived from multiple-testing correction across the 7 SNPs and eight DMN measures examined in this analysis. rs130058 is located in HTR1B, rs7997012 is in HTR2A. Age, sex, and the first two genetic PCs were included as covariates. Angular, Angular Gyrus; mPFC, Medial Prefrontal Cortex; MTG, Middle Temporal Gyrus.