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. 2016 Apr 5;24(6):1019–1029. doi: 10.1038/mt.2016.53

Figure 2.

Figure 2

Effect of SRT on GL-1 and lyso-GL-1 concentrations in the hindbrains of CBE-treated C57Bl/6 mice. The hindbrain from untreated (control), CBE-treated (dosed IP at 100 mg/kg/day) (CBE), and CBE- and Genz-682452-treated (dosed in the diet at ~60 mg/kg/day) (CBE+SRT) C57Bl/6 mice were analyzed for total GL-1 (a), GL-1 isoforms with an acyl chain carbon length of <21 (b), GL-1 isoforms with an acyl chain carbon length of >21 (c), and lyso-GL-1 (d) at the end of the study period (after 7 weeks of treatment, which corresponded to 11 weeks of age). Individual data points (n = 10 per group) and mean ± SD are presented. Data were analyzed using one-way ANOVA with Tukey's post-test; ns = not significant, *P < 0.05, ***P < 0.001, ****P < 0.0001. CBE, conduritol β epoxide; GL-1, glucosylceramide; SRT, substrate reduction therapy.