Skip to main content
. 2016 Apr 5;24(6):1019–1029. doi: 10.1038/mt.2016.53

Figure 4.

Figure 4

Effect of SRT on hind limb splay in CBE-treated C57Bl/6 mice. The hind limb splay response was observed by suspending mice by their tails and was assessed in a blinded manner using a scale of 0 (normal WT response) to 5 (severe deficit with no splay response). The splay response of untreated (control), CBE-treated (dosed intraperitoneally at 100 mg/kg/day) (CBE), and CBE- and Genz-682452-treated (dosed in the diet at ~60 mg/kg/day) (CBE+SRT) C57Bl/6 mice was assessed at the indicated time points. Higher numbers indicate a greater deviation from the normal response (lesser extent of hind limb splay and increased paw clenching). Data were analyzed using one-way ANOVA with Tukey's post-test between the CBE and CBE+SRT groups; *P < 0.05, ***P < 0.001. CBE, conduritol β epoxide; SRT, substrate reduction therapy; WT, wild-type.