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. 2016 May 3;24(6):1126–1134. doi: 10.1038/mt.2016.64

Figure 1.

Figure 1

Expansion of CD4+ regulatory T-cells (Treg) after alloanergization is maintained in proinflammatory conditions. (a) FOXP3+ Treg, expressed as percentage of total CD4+ cells, after alloanergization and repeated exposure to alloantigen in the absence or presence of lipopolysaccharide (LPS). Graph depicts results from eight different HLA-mismatched stimulator-responder pairs. P values are for two-tailed student's t-test. Horizontal lines are medians. *P < 0.05, **P < 0.01, ns, not significant. (b) FOXP3+ Treg, expressed as percentage of total CD4+ cells, after alloanergization and repeated exposure to alloantigen in the absence or presence of IL-1β and Il-6. Graph depicts results from seven different HLA-mismatched stimulator-responder pairs. P values are for two-tailed student's t-test. Horizontal lines are medians. *P < 0.05, **P < 0.01, ns, not significant.