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| Genetic factors |
| Major histocompatibility genes (HLA) |
| Immunoregulatory genes (CTLA4, PTPN22, FOXP3, CD25, CD40, FRCL3) |
| Thyroid specific genes (TSHR, Tg) |
| Environmental factors |
| Iodine intake |
| Smoking |
| Alcohol |
| Selenium |
| Vitamin D |
| Infections |
| Stress |
| Drugs (estrogens) |
| Existential factors |
| Female sex |
| Parity |
| Age |
