Table 2. Means for Thyroid Hormone Levels by Select Metabolic Syndrome Components.
Variable | No. (%) | Thyroid hormones | |||
---|---|---|---|---|---|
TSH, mU/L | T3, nmol/L | T4, nmol/L | T3-to-T4 ratio | ||
BMI, kg/m2 | |||||
Underweight (<18.5) | 219 (2) | 2.6±1.3a,* | 1.67±0.28a,* | 109.7±17.4a,‡ | 0.015±0.003a,* |
Normal (18.5-24.9) | 8,992 (66) | 2.4±1.3a,* | 1.71±0.28b,* | 108.8±17.9a,‡ | 0.016±0.003b,* |
Overweight (25-29.9) | 4,042 (30) | 2.2±1.2b,* | 1.75±0.28c,* | 108.0±17.9b,‡ | 0.017±0.003c,* |
Obesity (≥30) | 243 (2) | 2.2±1.2b,* | 1.79±0.26d,* | 110.9±20.0c,‡ | 0.017±0.003c,* |
Systolic BP, mm Hg | |||||
<130 | 10,272 (76) | 2.3±1.3 | 1.71±0.28* | 108.3±17.8* | 0.016±0.003† |
≥130e | 3,224 (24) | 2.3±1.3 | 1.76±0.29* | 109.7±18.3* | 0.017±0.003† |
Diastolic BP, mm Hg | |||||
<85 | 10,756 (80) | 2.3±1.3 | 1.71±0.28* | 108.3±17.8* | 0.016±0.003‡ |
≥85e | 2,739 (20) | 2.3±1.3 | 1.76±0.29* | 109.9±18.5* | 0.017±0.003‡ |
HDL-C, mg/dL | |||||
Lowf | 1,555 (12) | 2.5±1.3* | 1.68±0.28* | 108.8±17.7 | 0.016±0.003* |
Highg | 11,941 (88) | 2.3±1.3* | 1.73±0.28* | 108.6±17.9 | 0.017±0.003* |
Triglycerides, mg/dL | |||||
<150 | 9,966 (74) | 2.3±1.3 | 1.70±0.28* | 108.8±17.9 | 0.016±0.003* |
≥150 | 3,530 (26) | 2.4±1.3 | 1.80±0.28* | 108.1±18.1 | 0.017±0.003* |
Fasting glucose, mg/dL | |||||
<100 | 11,484 (85) | 2.4±1.3* | 1.72±0.28* | 108.6±17.8 | 0.016±0.003* |
≥100h | 2,012 (15) | 2.2±1.2* | 1.75±0.29* | 108.6±18.6 | 0.017±0.003* |
HbA1c, % | |||||
<5.7 | 10,636 (79) | 2.4±1.3a,‡ | 1.72±0.28a,* | 108.5±17.8a,† | 0.016±0.003a,* |
5.7-6.4 | 1,992 (15) | 2.3±1.3a,b,‡ | 1.75±0.29b,* | 108.6±17.8a,† | 0.017±0.003b,* |
≥6.5h | 868 (6) | 2.2±1.3b,‡ | 1.73±0.30a,* | 110.4±19.6b,† | 0.016±0.003a,* |
Values are expressed as mean±SD. Thyroid hormone levels of the study population with respect to the cut-off values of metabolic syndrome components were compared using an independent t test or one-way analysis of variance as appropriate for the variable.
TSH, thyroid stimulating hormone; T3, triiodothyronine; T4, thyroxine; BMI, body mass index; BP, blood pressure; HDL-C, high density lipoprotein cholesterol; HbA1c, glycated hemoglobin.
a,b,c,dThe same letters indicate non-significant difference between groups based on Tukey's multiple comparison test; eInclude patients on antihyper-tensive medication regardless of systolic or diastolic BP levels; fHDL-C <40 mg/dL in men or <50 mg/dL in women; gHDL-C ≥40 mg/dL in men or ≥50 mg/dL in women; hInclude patients on antidiabetic medication regardless of fasting glucose or HbA1c levels; *P<0.001; †0.001≤P<0.01; ‡0.01≤P<0.05.