Fig. 2. Effects of resveratrol (RSV) on metabolic parameters in Otsuka Long Evans Tokushima Fatty (OLETF) rats. (A) Body weight changes after RSV treatment of OLETF rats. RSV had been provided since the age of 9 weeks and maintained for 27 weeks. (B) Insulin tolerance test of OLETF rats at 35 weeks of age. (C) Organ weights at 36 weeks of age. (D) Changes in leptin and adiponectin levels. Serum samples from 36-week-old rats were collected and evaluated with an enzyme-linked immunoassay kit. SD, standard diet; HF, high fat; AUC, area under the curve. ^aP value below 0.05 with treatment of RSV in each diet group (Mann-Whitney U test).