Table 1. Agents favoring oxidative stress for targeting AML-stem cells.
| Targeting agents | Molecular structure | Involved mechanisms | Ref |
|---|---|---|---|
| Niclosamide |  |
ROS induction | (30) |
| NF-κB inactivation | |||
| ABT-737 |  |
BCL-2 inhibition | (31) |
| ROS-induction | |||
| GSH depletion | |||
| ABT-263 |  |
OXPHOS inhibition | (31) |
| ATP depletion | |||
| Glycolysis inhibition | |||
| Celastrol |  |
ROS induction | (29) |
| NF-κB inactivation | |||
| HNE |  |
ROS induction | (29) |
| NF-κB inactivation | |||
| DZNep |  |
ROS induction | (33) |
| ER stress | |||
| Mefloquine |  |
ROS induction | (32) |
| Lysosome disruption | |||
| PTL |  |
ROS induction | (26) |
| p53 activation | |||
| NF-κB inactivation | |||
| DMAPT |  |
ROS induction | (27) |
| p53 activation | |||
| NF-κB inactivation | |||
| Fenretinide |  |
ROS induction | (34) |
| NF-κB inactivation | |||
| Wnt inhibtion | |||
| TDZD-8 |  |
ROS induction | (25) |
| Membrane disruption | |||
| PKC inhibition | |||
| FLT3 inhibition |
AML, acute myeloid leukemia; HNE, 4-hydroxy-2-nonenal; DZNep, 3-deazaneplanocin A; PTL, parthenolide; DMAPT, dimethylaminoparthenolide; TDZD-8, 4-benzyl, 2-methyl, 1,2,4-thiadiazolidine, 3,5 dione; ROS, reactive oxygen species; NF-κB, nuclear factor kappa B; GSH, glutathione; ER, endoplasmic reticulum; FLT3, fms-like tyrosine kinase-3.