Figure 3.

Schematic representation of multifunctional nanoparticles targeted to tumor cells and CSCs. Administration of multifunctional nanoparticles that consists of an inner core containing paramagnetic iron oxide (imaging), and middle layer containing a chemotherapeutic (cisplatin) and an outer layer containing a chemosensitizing agent (gefitinib) that is decorated with EGFR and c-Kit targeting moieties will result in killing of both tumor cells and cancer stem cells. The delivery of the nanoparticles and response to therapy can be monitored non-invasively by magnetic resonance imaging.