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Pioglitazone downregulated the proinflammation in MNC. (a)–(c) Change in mRNA expression of peripheral blood mononuclear cells (MNC). The mRNA levels of IL-6, TNF-α, and MMP-9 were detected by quantitative real-time PCR. (d) NF-κB DNA binding activity was detected. (e) The expression of p50 subunit and p65 subunit in MNC. ∗ P < 0.05 and ∗∗ P < 0.01 compared with baseline.
