Fig.4.

Change from baseline to final assessment in Alzheimer’s Disease Assessment Scale-Cognitive Subscale total score by apolipoprotein E (APOE)-ɛ4 allele copy number. A) Placebo-corrected change from baseline to the final visit with donepezil treatment in the intent-to-treat (ITT) and completer populations. p-values are for the comparison of donepezil treatment effect versus placebo. B) Least square (LS) mean change from baseline values for the donepezil and placebo treatment groups (ITT population). Error bars in panel B represent standard error. NS, not significant.