ATP-induced bladder responses in bladder strips from controls and 6-OHDA-lesioned rats. Cumulative administration of ATP showed a trend to yield an overall higher contraction in the 6-OHDA-lesioned rats (n = 10) as compared to controls (n = 27; A). This was evident in particular at the highest concentration (5×10 −
3 M; A, C). A significant difference was observed following atropine administration, where a higher response was shown in the bladder strips from the 6-OHDA-lesioned animals (n = 10) as compared to control animals (n = 26; B). * = significantly different from control group. [Two-way repeated ANOVAs; (A) interaction: F(6, 210) = 1.69, p = 0.12, (B) interaction: F(6, 204) = 1.85, p = 0.092, Group: F(1, 34) = 8.40, p = 0.0065; All ANOVAS are followed by a Bonferroni multiple comparison test].