Fig.1.

Co-localization of HSV-1 DNA and amyloid-β in AD plaques. A strong co-localization showing HSV-1 DNA (brown staining using PCR) and amyloid plaque (blue staining using immunohistochemistry) in a postmortem AD brain (G). Greater than 90% AD plaques contained viral DNA. Scale bar = 50μm. Figure from Wozniak, MA, Mee AP, Itzhaki RF (2009) Herpes simplex virus type 1 DNA is located within Alzheimer’s disease amyloid plaques. J Pathol 217, 131-138 [3]. Copyright 2008. Reprinted with permission from John Wiley and Sons, Inc. and Ruth Itzhaki.