Table 2.
APOE genotypes of Alzheimer’s disease patients and aged non-Alzheimer’s disease patients positiveor negative for Herpes Simplex Virus Type 1 in all brain regions
| Overall data for all brain regions | ||||||
| Non-AD (n = 44) | AD (n = 46) | |||||
| HSV1+ | HSV1– | Total | HSV1+ | HSV1– | Total | |
| Genotype | ||||||
| ɛ2/ ɛ2 | 0 | 0 | 0 | 0 | 0 | 0 |
| ɛ2/ ɛ3 | 1 | 3 | 4 | 2 | 1 | 3 |
| ɛ2/ ɛ4 | 0 | 0 | 0 | 0 | 0 | 0 |
| ɛ3/ ɛ3 | 25 | 11 | 36 | 5 | 7 | 12 |
| ɛ3/ ɛ4 | 2 | 2 | 4 | 20 | 2 | 22 |
| ɛ4/ ɛ4 | 0 | 0 | 0 | 9 | 0 | 9 |
| Allele number | ||||||
| ɛ2 | 1 | 3 | 4 | 2 | 1 | 3 |
| ɛ3 | 53 | 27 | 80 | 32 | 17 | 49 |
| ɛ4 | 2 | 2 | 4 | 38 | 2 | 40 |
| APOE- ɛ4 | 3.6% | 6.3% | 4.5% | 52.8% | 10.0% | 43.4% |
HSV-1 in brains of APOE-ɛ4 allele carriers accounts for over 50% of AD brains with testing done postmortem. Table from Itzhaki RF, Lin WR, Shang D, Wilcock GK, Faragher B, Jamieson GA (1997) Herpes simplex virus type 1 in brain and risk of Alzheimer’s disease. Lancet 349, 241-244 [49]. Copyright 1997. Reprinted with permission from Elsevier and Ruth Itzhaki.