Table 1.

Anti-microbial therapy

Antibiotic	Route	Adult dosage/day	Dosage:mg/kg/day	Duration (in days)
First-line antibiotics :
Chloramphenicol	Oral, IV	500 mg qid	50 mg/kg in 4 doses @	14
Trimethoprim-Sulfamethoxazole	Oral, IV	160/800 mg bid	4-20 mg/kg: in 2 doses	14
Ampicillin/Amoxycillin	Oral, IM, IV	1000-2000 mg qid	50-100 mg/kg: in 4 doses	14
Second-line antibiotics:
Fluoroquinolones
Ciprofloxacin	Oral/IV	500 mg bid/200 mg bid	NA	10-14
Norfloxacin	Oral	400 mg bid	NA	10
Pefloxacin	Oral, IV	400 mg bid	NA	10
Ofloxacin	Oral	400 mg bid	NA	14
Ceph alosporins
Ceftriaxone	IM, IV	1-2 gm bid	50-75 mg/kg: in 1-2 doses	7-10
Cefotaxime	IM, IV	1-2 gm bid	40-80 mg/kg: in 2-3 doses	14
Cefoperazone	IM, IV	1-2 gm bid	50-100 mg/kg: in 2 doses	14
Cefixime	Oral	200-400 mg od/bid	10 mg/kg: in 1-2 doses	14
Other antibiotics:
Aztreonam	IM	1 gm/bd-qid	50-70 mg/kg: 2-4	5-7
Azithromycin	Oral	1 gm od	5-10 mg/kg:1	5

^@Dose of chloramphenicol may be reduced to 25 mg/kg after defervescence.