TABLE 6.
Comparison of signature peptides between Cognis' FAO1, FAO2a, FAO2b, C. albicans FAO, and C. tropicalis FAOT
| Peptide | Sequencea
|
||||
|---|---|---|---|---|---|
| Signature peptideb | FAOT | FAO1 | FAO2a and FAO2b | FAO-CAc | |
| 1 | IIGSG(X)GAGVVA | IIGSGAGAGVVA | IIGSGAGAGVVA | IIGSGAGAGVMA | IIGSGAGSGVVA |
| 2 | AGSTFGGG | AGSTFGGG | AGSTFGGG | AGSTLGGG | AGSTFGGG |
| 3 | NWSACLKTP | NWSACLKTP | NWSACLKTP | NWSACLKTP | NWSACIKTP |
| 4 | CG(X)CHLGC | CGFCHLGC | CGFCYLGC | CGFCYLGC | CGFCHLGC |
| 5 | IG(X)NL(X)LHPVS | IGKNLTLHPVS | IGKNLTLHPVS | IGKNLTLHPVS | IGANLTLHPVT |
| 6 | SAHQMS(X)CRMSG | SAHQMSTCRMSG | SAHQMSTCRMSG | SAHQMSTCRMSG | SAHQMSSCRMSG |
| 7 | PTASG(X)NPM | PTASGANPM | PTASGANPM | PTASGANPM | PTASGANPM |
a
Amino acid in bold indicate amino acid differences from signature peptide. (X) indicates that any amino acid may be at this position.
b
A. R. Slabas, K. Elborough, S. Vanhanen, M. West, Q. Cheng, N. Lindner, J. Casey, and D. Sanglard, 23 September 1999. International patent application WO 99/47685.
c
Putative FAO from C. albicans.