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. 2016 Jun 28;6:28712. doi: 10.1038/srep28712

Table 3. Subgroup analysis of cerebral metabolites in the white matter and frontal cortex.

Study OSA Control Weight% WMD [95%CI] p I2% p PBegg PEgger
NAA/Cr in frontal white matter
 Alchanatis et al.35 1.59 ± 0.16 1.74 ± 0.15 34.3 −0.15 [−0.26, −0.04]          
 Algin et al.33 1.72 ± 0.8 2.15 ± 0.1 31.5 −0.43 [−0.76, −0.10]          
 Gharraf et al.36 1.13 ± 0.13 2.08 ± 0.15 34.3 −0.95 [−1.06, −0.84]          
 Pooled     100 −0.51 [−1.11, 0.09] <0.01 98 0.09 0.30 0.07
Cho/Cr in frontal white matter
 Alchanatis et al.35 1.01 ± 0.15 1.19 ± 0.17 32.0 −0.18 [−0.30, −0.06]          
 Algin et al.33 1.23 ± 0.1 1.05 ± 0.1 33.6 0.18 [0.10, 0.26]          
 Gharraf et al.36 0.99 ± 0.08 1.17 ± 0.03 34.3 −0.18 [−0.22, −0.14]          
 Pooled     100 −0.06 [−0.31, 0.19] <0.01 97 0.64 0.99 0.72
NAA/Cr in frontal cortex
 Alchanatis et al.35 1.56 ± 0.12 1.58 ± 0.15 51.5 −0.02 [−0.13, 0.09]          
 Algin et al.33 1.5 ± 0.4 1.8 ± 0.1 45.0 −0.30 [−0.47, −0.13]          
 Halbower et al.26 3.1 ± 1.7 2.7 ± 0.6 3.4 0.40 [−0.95, 1.75]          
 Pooled     100 −0.13 [−0.39, 0.13] 0.02 75 0.32 0.99 0.60
NAA/Cho in frontal cortex
 Alchanatis et al.35 2.18 ± 0.35 2.07 ± 0.36 34.1 0.11 [−0.15, 0.37]          
 Algin et al.33 1.44 ± 0. 1 2.26 ± 0.3 34.9 −0.82 [−1.02, −0.62]          
 Halbower et al.26 1.6 ± 0.4 2.2 ± 0.4 31.0 −0.60 [−1.04, −0.16]          
 Pooled     100 −0.43 [−1.07, 0.20] <0.01 94 0.18 0.30 0.26
Cho/Cr in frontal cortex
 Alchanatis et al.35 0.74 ± 0.13 0.78 ± 0.13 15.9 −0.04 [−0.14, 0.06]          
 Algin et al.33 1 ± 0.04 1 ± 0.06 83.9 0.00 [−0.04, 0.04]          
 Halbower et al.26 1.9 ± 1.1 1.3 ± 0.3 0.2 0.60 [−0.25, 1.45]          
 Pooled     100 −0.01 [−0.04, 0.03] 0.29 20 0.80 0.30 0.22

NAA, N-acetylaspartate; Cho, choline; Cr, creatine; OSA, Obstructive sleep apnea; MD, Mean difference; CI, Confidence Interval; PBegg, p-value of Begg’s test; PEgger, p-value of Egger test.