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Amino acid substitutions of the variants
| Variant | Amino acid substitutions |
|---|---|
| First-round shuffling variants | |
| A1030 | A14T, A80V, K185R, I274N |
| A1467 | A14T, R67H, A80V, L87S, Q148R, K185R |
| Second-round shuffling variants | |
| B1368 | A14T, A80V, K185R |
| B2136 | A14T, A80V, K185R, H254R, I274N |
| B3561 | A14T, L17P, A80V, V116I, K185R, A203T, I274N, P342S |
