Table 4. Permeation parameters of CUR formulations through the excised corneas (mean ± S.D., n = 3).

	Eye drops	NLC	CH-NLC	CS-NACL-NLC	CS-NACM-NLC	CS-NACH-NLC
Jss (0–60 min) (×10−4 μg·cm−2·s−1)	3.20 ± 0.35	10.13 ± 0.21a	15.3 ± 0.33a,b	46.06 ± 0.15a,b,c	57.65 ± 0.61a,b,c,d	65.56 ± 0.64a,b,c,d,e
Jss (60–360 min) (×10−4 μg·cm−2·s−1)	1.66 ± 0.07	3.30 ± 0.06a	5.12 ± 0.03a,b	14.98 ± 0.07a,b,c	20.05 ± 0.06a,b,c,d	21.4 ± 0.34a,b,c,d
Papp (0–60 min) (×10−6 cm·s−1)	0.54 ± 0.04	1.69 ± 0.09a	2.55 ± 0.02a,b	7.67 ± 0.11a,b,c	8.71 ± 0.06a,b,c,d	10.90 ± 0.21a,b,c,d,e
Papp (60–360 min) (×10−6 cm·s−1)	0.19 ± 0.01	0.56 ± 0.02a	0.85 ± 0.02a,b	2.99 ± 0.12a,b,c	3.35 ± 0.10a,b,c,d	3.57 ± 0.05a,b,c,d
R2(0–60 min)	0.9954 ± 0.0017	0.9994 ± 0.0005	0.9998 ± 0.0004	0.9986 ± 0.0012	1.0000 ± 0.0003	0.9998 ± 0.0002
R2(60–360 min)	0.9981 ± 0.0023	0.9997 ± 0.0008	0.9953 ± 0.0001	1.0000 ± 0.0002	0.9999 ± 0.0013	0.9999 ± 0.0011

^aStatistically significant compared with the eye drops (p < 0.05).

^bStatistically significant compared with the NLC (p < 0.05).

^cStatistically significant compared with the CH-NLC (p < 0.05).

^dStatistically significant compared with the CS-NAC_L-NLC (p < 0.05).

^eStatistically significant compared with the CS-NAC_M-NLC (p < 0.05).