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. 2016 Jun 28;6:28720. doi: 10.1038/srep28720

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(a,c) Unsupervised hierarchical clustering of tumor growth module and substance biosynthetic and metabolic module of AML. According to expression profiles of 1484 genes and 738 genes in two modules, 151 patients were clustered into two groups. The blue bar above the patients indicates the low risk group, the red bar indicates the patients with high risk. (b,d) Kaplan-Meier survival plots of low risk and high risk AML patients based on the hierarchical clustering results of (a,b) The gene expression signature of the patients in high risk (red lines) with a significantly increased risk of death when compared to low risk group (blue lines).