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. 2016 Jun 28;6:28720. doi: 10.1038/srep28720

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(a,c) Unsupervised hierarchical clustering of apoptosis and tumors migration module and nervous system development module of neuroblastoma. According to expression profiles of 3334 genes and 1739 genes in two modules, 236 patients were clustered into two groups. The blue bar above the patients indicates the low risk group, the red bar indicates the patients with high risk. (b,d) Kaplan-Meier survival plots of low risk and high risk neuroblastoma patients based on the hierarchical clustering results of (a,b) The gene expression signature in apoptosis and tumors migration module of the patients in high risk (red lines) with a significantly increased risk of death when compared to low risk group (blue lines).