Figure 5. Unsupervised hierarchical clustering of genes in two modules and the Kaplan-Meier analysis of the independent testing set of 237 neuroblastoma patients.

(a,c) Unsupervised hierarchical clustering of two modules of independent testing set. According to expression profiles of 3334 genes and 1739 genes in two modules, 237 patients were clustered into two groups. The blue bar above the patients indicates the low risk group, the red bar indicates the patients with high risk. (b,d) Kaplan-Meier survival plots of low risk and high risk neuroblastoma patients based on the hierarchical clustering results of (a,b). The gene expression signature in module I of the patients in high risk (red lines) with a significantly increased risk of death when compared to low risk group (blue lines).