TABLE 1.

Protocol for investigation of cases of prolonged fever undergoing treatment for pulmonary tuberculosis

1. Complete blood counts done weekly

2. Peripheral smears for toxic granulation, type of anemia, haemoparasites. abnormal cells

3. Bone marrow studies*

4. Blood cultures

5. Urine pyogenic cultures and MTB cultures

6. Sputum studies

7. Tuberculin test (1 TU)

8. Serial review of CXR

9. Ultra sound chest wall and abdomen

10. Anti-nuclear antibodies*

11. Cerebrospinal fluid examination*

12. CT scan chest and / or abdomen*

13. Bronchoscopy, lavage, biopsy*

14. Eliminate suspect drug

15. Repeated detailed clinical examination

^*where indicated; MTB – mycobacterium tuberculosis