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. Author manuscript; available in PMC: 2016 Jun 28.
Published in final edited form as: Ann N Y Acad Sci. 2014 Feb 3;1310:44–50. doi: 10.1111/nyas.12361

Figure 1.

Figure 1

A simple proposed model of relationships among stem cell quiescence, self-renewal and differentiation, exhaustion, senescence and development of disease. Modified from Jacob and Osato,19 and van Zant and Liang.20