Table 1.
Genotypic resistance mutations identified and antiretroviral resistance profile in pregnant women with perinatally-acquired HIV infection.
| Patient Number | Subtype | Protease Inhibitors (PI) | Reverse Transcriptase Inhibitor Mutations | Resistance Profile | ||||
|---|---|---|---|---|---|---|---|---|
| Major Mutations | Minor Mutations | NRTI | NNRTI | Low | Intermediate | High | ||
| 1 | NR | 0 | L10V | 0 | 0 | |||
| 2 | B | 0 | L10V | 0 | 0 | |||
| 3 | B | 0 | 0 | 0 | 0 | |||
| 4 | B | 0 | K20T A71T | M41L M184V T215D | K101P K103NS Y188HL | TDF NFV |
ABC ZVD D4T DDI | 3TC FTC EFV ETR NVP RVP |
| 5 | F1 | 0 | L10I | M184V T215Y | V90I K103N E138A | DDI RPV |
ABC ZVD D4T | 3TC FTC EFV NVP |
| 6 | B | 0 | 0 | D67N T69D M184V K219Q | A98G Y181C H221Y | ABC ZVD D4T | DDI EFV ETR RPV | 3TC FTC NVP |
| 7 | B | V32I M46I I47A | L10I A71V | M41L D67N V75M M184V L210W T215Y K219N | K103N | ATZ/r DRV/r IDV/r TPV/r | ABC ZVD D4T DDI 3TC FTC TDF EFV NVP FSP/r NFV LPV/r |
|
| 8 | F1 | 0 | L10V | 0 | K103N | EFV NVP | ||
| 9 | B | 0 | 0 | 0 | 0 | |||
| 10 | B | M46L I54IV V82AV L90LM | L10F L33F G73AG | M41L T215S K219R | K103N | 3TC FTC DRV/r |
ABC DDI TDF TPV/r |
ZVD D4T EFV NVP ATZ/r FSP/r IDV/r LPV/r NFV SQV/r |
| 11 | F1 | 0 | 0 | 0 | K103N V106I | EFV NVP | ||
| 12 | B | M46I I54V L76V V82A | L10V A71V | D67N T69N K70R M184V K219Q | 0 | TDF DRV/r TPV/r |
ABC D4T DDI ATZ/r SQV/r |
ZVD 3TC FTC FSP/r IDV/r LPV/r NFV |
| 13 | B/F | 0 | A71V | 0 | 0 | |||
| 14 | F1 | 0 | 0 | D67N K70R M184V K219Q | K103N P225H | TDF | ABC AZT D4T DDI | 3TC FTC EFV NVP |
| 15 | B | 0 | 0 | M184V | K103N | DDI ABC | 3TC FTC EFV NVP |
|
| 16 | B | 0 | 0 | M184V | V179D Y188L | ABC ETR |
3TC FTC EFV NVP RPV |
|