Table 3.
Association of the MTHFR C677T polymorphism with risk of essential hypertension.
| MTHFR C677T | Hypertension, n (%) | Normotensive, n (%) | Crude OR (95% CI) |
p-Value | Adjusted OR (95% CI) | p-Value |
|---|---|---|---|---|---|---|
| Codominant | ||||||
| CC | 37 (17.29) | 119 (24.09) | 1.0 (reference) | 1.0 (reference) | ||
| CT | 102 (47.66) | 234 (47.37) | 1.40 (0.91–2.17) | 0.129 | 1.53 (0.96–2.45) | 0.075 |
| TT | 75 (35.05) | 141 (28.54) | 1.71 (1.08–2.72) | 0.023 | 1.81 (1.10–2.98) | 0.020 |
| Dominant | ||||||
| CC | 37 (17.29) | 119 (24.09) | 1.0 (reference) | 1.0 (reference) | ||
| CT + TT | 177 (82.71) | 375 (75.91) | 1.52 (1.01–2.29) | 0.046 | 1.64 (1.05–2.55) | 0.029 |
| Recessive | ||||||
| CC + CT | 139 (64.95) | 353 (71.46) | 1.0 (reference) | 1.0 (reference) | ||
| TT | 75 (35.05) | 141 (28.54) | 1.35 (0.96–1.90) | 0.085 | 1.34 (0.93–1.94) | 0.120 |
| Allele | ||||||
| C | 176 (41.12) | 472 (47.77) | 1.0 (reference) | |||
| T | 252 (58.88) | 516 (52.23) | 1.31 (1.04–1.65) | 0.021 | ||
Abbreviations: MTHFR, methylenetetrahydrofolate reductase; OR, odds ratio; CI, confidence interval. Adjusted OR: adjusted for age, gender, BMI, smoking and drinking status. p-Value < 0.05 was considered statistically significant.