Table 3.
The adjusted subgroup characteristics of possible risk factors associated with HCC in HBsAg-positive Chinese population.
| Risk Factors | No. of Studies (Cases/Controls) | OR | M | Heterogeneity | PH | I2 (%) | Egger’s Test | p | Begg’s Test | p | Omitted Reference | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | Z | POR | X2 | t | Z | ||||||||
| subgroup analyses by high HBV DNA levels | 9 (1066/4400) | 3.89 (3.18, 4.77) | 13.10 | <0.05 | F | 8.30 | >0.1 | 4% | −0.76 | >0.1 | −0.1 | >0.1 | [21,25,34] |
| subgroup analyses by alcohol consumption | 10 (1247/3700) | 1.65 (1.35, 2.02) | 4.89 | <0.05 | F | 13.59 | >0.1 | 34% | 1.73 | >0.1 | 1.43 | >0.1 | [25,26] |
| subgroup analyses by HBeAg positive | 4 (409/3066) | 3.00 (2.28, 3.94) | 7.86 | <0.05 | F | 4.12 | >0.1 | 27% | 0.19 | >0.1 | −0.34 | >0.1 | [13,22,25,35] |
| subgroup analyses by smoking | 4 (608/3242) | 2.20 (1.64, 2.95) | 5.25 | <0.05 | F | 4.22 | >0.1 | 29% | 2.03 | >0.1 | 1.02 | >0.1 | [23,24,36] |
Abbreviations: HCC = hepatocellular carcinoma; OR = Odds ratio; CI = confidence intervals; M = model; F = fixed-effect model.