Figure 5. miR-675 directly targeted the 3′ untranslated regions (UTRs) of HDAC 4, 5, and 6 transcriptions.
(A) Schematic diagrams of the wild-type and mutant binding sites of miR-675 located in the 3′UTRs of HDAC 4, 5, and 6 transcriptions. (B) Schematic showing the constructed luciferase reporter system containing the binding sites of miR-675. (C) Luciferase activity of 293T cells co-transfected with 100 nM miR-675 mimic or miRNA mimic control (mimic NC) and the luciferase constructs carrying the 3′UTR of HDAC 4, 5, or 6. Results are shown as mean ± SD (**P < 0.01).