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. 2016 Jun 28;6:29052. doi: 10.1038/srep29052

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(A,B) Metabolite maps of nCr and nNAA of a 42-year old patient (BT_447) with a GBM in the right frontal lobe. Metabolite maps were overlaid on a contrast-enhanced T1-weighted image. The volume of interest (PRESS volume) is indicated in yellow, the reference voxel for metabolite concentration normalisation in green. It has to be noted that the high nNAA concentration in one voxel in the centre of the tumour is due to erroneous peak assignment by LCModel. (C) Flow chart of study design and data preparation.