Table 3. Association between six genetic markers of inflammation and eight binary metabolic traits.
| Normal weight vs. obese | Normal weight vs. overweight and obese | Hypertension | Hyperglycemia | Dyslipidemia | Type 2 diabetes family history | Hypertension family history | Overweight/obesity family history | |
|---|---|---|---|---|---|---|---|---|
| rs1137101 (LEPR) | 0.052 [0.886–1.253] (0.56) | 1.004 [0.867–1.162] (0.96) | 1.415 [0.782–2.562] (0.25) | 0.774 [0.505–1.186] (0.24) | 0.995 [0.853–1.161] (0.95) | 0.883 [0.706–1.105] (0.28) | 0.861 [0.707–1.049] (0.14) | 0.925 [0.799–1.072] (0.30) |
| rs7305618 (HNF1A) | 0.849 [0.652–1.106] (0.23) | 0.879 [0.704–1.097] (0.25) | 0.732 [0.263–2.038] (0.55) | 0.938 [0.485–1.816] (0.85) | 0.871 [0.688–1.102] (0.25) | 1.347 [0.988–1.837] (0.06) | 1.389 [1.054–1.829] (0.02) | 1.050 [0.841–1.311] (0.67) |
| rs1800629 (TNFA)a | 1.175 [0.767–1.799] (0.46) | 1.111 [0.767–1.609] (0.58) | 1.110 [0.260–4.736] (0.89) | 0.793 [0.244–2.576] (0.70) | 1.084 [0.738–1.592] (0.68) | 0.652 [0.336–1.266] (0.21) | 0.553 [0.300–1.018] (0.06) | 1.020 [0.702–1.482] (0.92) |
| rs1800896 (IL-10) | 1.011 [0.825–1.239] (0.92) | 1.050 [0.883–1.249] (0.58) | 0.827 [0.393–1.743] (0.62) | 1.348 [0.834–2.180] (0.22) | 1.041 [0.868–1.238] (0.67) | 1.060 [0.813–1.383] (0.67) | 0.991 [0.785–1.253] (0.94) | 1.104 [0.927–1.314] (0.27) |
| rs1800871 (IL-10) | 0.929 [0.778–1.108] (0.41) | 0.962 [0.827–1.118] (0.61) | 0.851 [0.457–1.584] (0.61) | 1.152 [0.750–1.769] (0.52) | 0.944 [0.805–1.107] (0.48) | 1.015 [0.807–1.277] (0.90) | 0.876 [0.714–1.075] (0.20) | 0.906 [0.779–1.054] (0.20) |
| rs1862513 (RETN) | 0.785 [0.585–1.052] (0.11) | 0.932 [0.736–1.180] (0.56) | 1.065 [0.416–2.726] (0.90) | 0.677 [0.310–1.477] (0.33) | 0.941 [0.733–1.209] (0.64) | 1.135 [0.801–1.609] (0.48) | 0.981 [0.713–1.350] (0.91) | 0.984 [0.777–1.246] (0.89) |
Notes:
Values in bold indicate P value < 0.05; data are presented as beta [confidence interval] (P-value).
a
SNP analyzed under the dominant mode.