Table 5.

Associations of LEPR Q223R and K656N polymorphisms with level of adipokines and body composition before and after 3-month intervention.

	LEPR Q223R A > G			LEPR K656N G > C
	Q223 (AA) (n = 22)	223R (AG + GG) (n = 54)	p AA vs. AG + GG	K656 (GG) (n = 60)	656N (GC + CC) (n = 16)	p GG vs. GC + CC
Baseline SDS-BMI	3.52 (3.11–4.12)	3.32 (2.60–5.05)	0.630	3.48 (2.65–4.75)	3.40 (2.96–5.74)	0.495
Delta SDS-BMI	−0.63 ± 0.53	−0.97 ± 0.50	0.010	−0.89 ± 0.53	−0.79 ± 0.55	0.494
Baseline fat mass (%)	40.2 (37.3–44.0)	41.1 (38.9–44.3)	0.464	40.7 (37.5–43.8)	42.2 (37.9–44.2)	0.499
Delta fat mass (%)	−0.8 ± 2.9	-3.3 ± 3.2	0.003	−2.9 ± 3.4	-1.2 ± 2.7	0.068
Baseline fat-free mass (kg)	29.7 ± 5.8	27.7 ± 7.4	0.114	28.2 ± 6.9	28.4 ± 7.3	0.819
Delta fat-free mass (kg)	−0.7 ± 1.1	−0.4 ± 1.2	0.402	−0.4 ± 1.2	-0.8 ± 1.0	0.342
Baseline Leptin (ng/mL)	44.0 (28.3–65.9)	37.0 (22.8–54.6)	0.166	37.0 (21.5–55.1)	46.0 (32.4–61.4)	0.125
Delta Leptin (ng/mL)	−26.6 ± 24.4	−21.2 ± 20.5	0.334	−22.2 ± 21.4	−24.9 ± 23.2	0.670
Baseline sOB-R (ng/mL)	22.0 (17.6–27.6)	23.1 (19.6–26.6)	0.639	23.1 (18.2–26.5)	22.3 (19.3–28.3)	0.828
Delta sOB-R (ng/mL)	1.2 ± 6.3	3.9 ± 6.7	0.108	4.0 ± 6.4	0.0 ± 6.9	0.032
Baseline Leptin/sOB-R	2.24 (1.09–3.29)	1.50 (0.89–2.50)	0.204	1.42 (.86–2.69)	2.27 (1.43–3.02)	0.198
Delta Leptin/sOB-R	−0.82 (−2.52–−0.15)	−0.85 (−1.68–−0.36)	0.891	−0.82 (-1.94–−0.34)	−1.02 (−2.07–−0.09)	0.674
Baseline Leptin/adiponectin	7.79 (5.37–11.86)	6.05 (3.32–9.98)	0.248	6.63 (3.34–10.63)	7.06 (5.13–10.98)	0.333
Delta Leptin/adiponectin	−4.5 ± 3.7	−4.0 ± 3.8	0.628	−4.22 ± 3.62	−3.72 ± 4.36	0.678

Results are presented as means ± standard deviations for normally distributed data, or medians and interquartile ranges (25th–75th percentiles) for non-normally distributed variables; SDS: standard deviation score, BMI: body mass index, sOB-R: soluble leptin receptor.