Table 2.

In vivo and in vitro anti-inflammatory effects of isoflavones.

Treatments	Dosage	Effects		Models	Reference
Genistein	30 mg/kg every 2nd day	Granulocytes, monocytes, and lymphocytes	↓	Mice	[44]
Soybean cake	0.3 mL aqueous solution	leukocyte number, IL-1β, IL-6, NO, and PGE2	↓	Mice	[46]
Soybean methanolic fraction	2.5 mg/kg	Acute toxicity Inflammation	↓	Mice	[47]
Puerarin	12.5 mg/kg	COX-2, astrocyte and microglia	↓	Mice	[48]
Genestein	5 mg/kg·BW/day	iNOS, COX-2, NF-ĸB, IKK α/β, MAPK	↓	Rats	[49]
Genestein	15 mg/kg	Bronchoconstriction, peroxidase	↓	Guinea pigs	[50]
Daidzein	400 mg/kg	Cxcl2 Poly-adenosine Diphosphate-ribosylation	↓	Murine lung epithelial cells	[52]
Genistein	10, 50, 100 μM	Cell morphology, ROS	↓	Vascular endothelial cells	[54]
Genistein	894 mg/kg	Metallothionein, IL-6, STAT3 Pro-inflammatory cytokine	↓	Mice, Caco-2 cells	[45]
		Mn-SOD	↑
Green soybean extract	50 mg/mL	IL-6, IL-12 and TNF-α expression levels	↓	Human THP-1	[53]