Table 1.
Cardiac function measurements on WT and RCM TG mice
| WT control | WT EGCg | RCM control | RCM EGCg | |
|---|---|---|---|---|
| Parameters | ||||
| Body weight (g) | 31.67 ± 1.53 | 30.67 ± 1.61 | 27.25 ± 1.21* | 28.35 ± 1.28* |
| Heart rate (bpm) | 470.72 ± 38.12 | 481.37 ± 44.15 | 450.75 ± 50.76 | 460.17 ± 49.73 |
| Atria | ||||
| LAEDD (mm) | 2.12 ± 0.02 | 2.13 ± 0.03 | 2.29 ± 0.04** | 2.21 ± 0.05*‡ |
| LAESD (mm) | 1.67 ± 0.03 | 1.69 ± 0.04 | 1.74 ± 0.06 | 1.71 ± 0.05 |
| RAEDD (mm) | 2.11 ± 0.05 | 2.12 ± 0.06 | 2.31 ± 0.11** | 2.26 ± 0.05* |
| RAESD (mm) | 1.71 ± 0.06 | 1.69 ± 0.03 | 1.64 ± 0.04 | 1.68 ± 0.05 |
| LV end diastole | ||||
| IVS (mm) | 0.75 ± 0.04 | 0.76 ± 0.03 | 0.75 ± 0.04 | 0.74 ± 0.03 |
| LVEDD (mm) | 3.88 ± 0.07 | 3.85 ± 0.04 | 3.42 ± 0.0 6* | 3.62 ± 0.03*‡ |
| LV PW (mm) | 0.76 ± 0.02 | 0.75 ± 0.04 | 0.76 ± 0.03 | 0.73 ± 0.03 |
| LV Volume (μl) | 64.67 ± 1.71 | 63.95 ± 2.16 | 46.16 ± 2.24** | 55.92 ± 1.19*‡ |
| LV end systole | ||||
| IVS (mm) | 1.27 ± 0.03 | 1.27 ± 0.04 | 1.24 ± 0.02 | 1.25 ± 0.03 |
| LVESD (mm) | 2.05 ± 0.05 | 2.08 ± 0.06 | 1.58 ± 0.02** | 1.75 ± 0.03*‡ |
| LV PW (mm) | 1.22 ± 0.03 | 1.22 ± 0.04 | 1.21 ± 0.03 | 1.21 ± 0.02 |
| LV Volume (μl) | 13.03 ± 0.43 | 13.42 ± 0.61 | 5.96 ± 0.71 | 9.35 ± 0.80**ǂǂ |
| Ejection Fraction (%) | 79.85 ± 1.41 | 79.01 ± 1.00 | 80.33 ± 1.91 | 80.57 ± 2.16 |
| Fractional Shortening (%) | 46.72 ± 1.22 | 45.38 ± 0.66 | 47.95 ± 1.84 | 47.44 ± 2.33 |
| Mitral Doppler | ||||
| E (mm/s) | 827.61 ± 22.05 | 829.75 ± 24.22 | 740.81 ± 18.93* | 809.04 ± 25.14 |
| A (mm/s) | 657.95 ± 12.34 | 667.35 ± 16.48 | 560.33 ± 33.66 * | 633.57 ± 26.83 |
| E/A | 1.26 ± 0.04 | 1.24 ± 0.02 | 1.32 ± 0.05 | 1.27 ± 0.05 |
| IVRT (ms) | 16.41 ± 0.44 | 16.44 ± 0.46 | 21.43 ± 0.54** | 18.53 ± 0.51*‡ |
| IVCT (ms) | 10.58 ± 0.33 | 11.05 ± 0.29 | 10.36 ± 0.75 | 10.86 ± 0.53 |
Values are expressed as means ± SE for each group. LA left atrium, RA right atrium, LV left ventricle, EDD end diastolic dimension, ESD end systolic dimension, PW posterior wall thickness of LV, IVS intra-ventricular septum, EF ejection fraction of LV, FS fractional shortening of LV, E mitral Doppler E peak velocity, A mitral Doppler A peak velocity, IVRT isovolumetric relaxation time, IVCT isovolumetric contraction time. Statistical significance was determined by ANOVA followed by post hoc Newman-Keuls (SNK) tests
*p <0.05 compared to WT control, **p <0.01 compared to WT control; ǂp <0.05 compared to RCM control; ǂǂp <0.01 compared to RCM control