Table 1.

Characteristics of randomized controlled trials included in the meta-analysis

Study	Preterm neonate	Number of neonates used in the analysis		Duration of prophylaxis (days)	Regimen	Average dosage of fluconazole (mg) /kg/day	Total dosage of fluconazole (mg)/kg	Research site	JADAD score
		Fluconazole	Control
Kaufman, 2001 [8]	ELBW	50	50	42	3 mg/kg every 3 days for weeks 1–2, every 2 days for weeks 3–4, and daily for weeks 5–6	1.83	77	Single	5
Kicklighter, 2001 [9]	VLBW	53	50	28	6 mg/kg every 3 days for week 1 and daily for weeks 2–4	5.00	140	Single	5
Manzoni, 2007 [10]	VLBW	216	106	28 or 42	3 or 6 mg/kg every 3 days for weeks 1–2, every 2 days for weeks 3–4 in VLBW, and every 2 days for weeks 3–6 in ELBW.	NA	NA	Multi	5
Parikh, 2007 [11]	VLBW	60	60	28	3 mg/kg every 3 days for week 1 and every day for weeks 2–4.	2.50	70	Single	5
Benjamin, 2014 [17]	ELBW	188	173	42	3 mg/kg every 3 days for weeks 1–2, every 2 days for weeks 3–4, and daily for weeks 5–6.	1.71	72	Multi	5

ELBW extremely-low-birth-weight, VLBW very-low-birth-weight, NA not applicable