Fig 5.

Effects of HE-Et and HE-My on the level of the proteins regulating Aβ accumulation and the level of NGF in cerebral cortex of APP/PS1 mice. Five months-old APP/PS1 mice were orally administered with vehicle (Veh, n = 6), HE-Et (n = 5) and HE-My (n = 5) for 30 days. Cortex was removed and homogenized, and the proteins involving in amyloidogenesis and amyloid clearance and NGF maturation in lysates were analyzed by immunoblotting. a The representative immunoblots of APP, CTF-α, −β, IDE, neprilysin and β-actin (left panel). The level of APP, CTF-α and -β, IDE and neprilysin was presented as percentage of control (Veh) (right panel). b The representative immunoblots of the proNGF, NGF and β-actin (left panel). The relative level of NGF/proNGF ratio was presented as percentage of control (Veh) (right panel). The results are the mean ± S.D. Significant differences between treated and control (Veh) groups are indicated by *, p < 0.05; **, p < 0.01