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. 2016 Jun 27;9:38. doi: 10.1186/s13048-016-0248-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — CRAd progeny amplification in OvCa cells. The titers of infectious viral progeny produced in OvCa cell lines were determined using the Viral ToxGlo assay (Promega) to measure cellular ATP level, as surrogate of cell viability. Monolayers of A549 cells were infected with serial dilutions of lysates of the indicated OvCa cells, which were infected with CRAd-ING4, CRAd-IL24, or control CRAd to determine a cytotoxic endpoint effect (50 % CPE or tissue culture infective dose TCID₅₀) 6 days postinfection. Each data point represents the cumulative mean ± SD (error bars are smaller than the symbols, p ≤ 0.05)