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. 2016 Jun 27;23:50. doi: 10.1186/s12929-016-0267-y

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — NAD + −induced transient AP prolongation in the presence of selective P2X antagonists in LA preparations. a relative APD90 measured at the moment of maximal AP prolongation in the absence of blockers and in the presence of P2X blockers iso-PPADS (1 μM) or Evans Blue (0.1 μM). APD90 is expressed in % of APD90 measured right before NAD+ application. * - significant difference from the effect of NAD+ alone, Mann–Whitney test, p < 0.05. b time course of APD90 changes induced by NAD+ in the presence of 0.1 μM Evans Blue and traces of APs recorded in the moments marked with numbers of respective color at the time course curve