Table 2.
Meta‐analysis of the reported common adverse effects in the included studies
| Adverse effect | Number of studies | Test of association | Test of heterogeneity | ||||
|---|---|---|---|---|---|---|---|
| RR | 95% CI | P | Q | I 2% | P | ||
| Fatigue | 5 | 0.762 | 0.418–1.388 | 0.374 | 1.92 | 0.0 | 0.751 |
| Dyspnea | 2 | 2.287 | 0.193–27.116 | 0.512 | 2.66 | 62.4 | 0.103 |
| Rash | 8 | 4.971 | 2.683–9.208 | 0.000 | 8.33 | 15.9 | 0.305 |
| Anorexia | 2 | 1.634 | 0.677–3.944 | 0.275 | 1.22 | 18.0 | 0.270 |
| Diarrhea | 8 | 1.506 | 0.938–2.417 | 0.090 | 5.00 | 0.0 | 0.660 |
| Headache | 4 | 1.070 | 0.657–1.743 | 0.786 | 2.68 | 0.0 | 0.443 |
| Anemia | 3 | 1.324 | 0.616–2.846 | 0.472 | 2.59 | 22.8 | 0.274 |
| Constipation | 2 | 1.799 | 0.652–4.964 | 0.256 | 0.11 | 0.0 | 0.739 |
| Dry skin | 2 | 8.438 | 1.475–48.278 | 0.017 | 0.50 | 0.0 | 0.477 |
| Nausea | 8 | 0.979 | 0.682–1.407 | 0.910 | 9.54 | 26.6 | 0.216 |
| Pneumonitis | 2 | 1.108 | 0.375–3.273 | 0.852 | 0.64 | 0.0 | 0.425 |
| Total | 8 | 1.247 | 1.012–1.572 | 0.009 | 6.99 | 12.9 | 0.213 |
RR, risk rate; CI, confidence interval.